Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation N acetylcysteine (NAC) Sex differences in glutathione metabolism and acetaminophen toxicity