Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect Pathology of G6PD deficiency Pathology Made Simple In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics